DRUGS

1. Aspirin 

• Low doses (typically 75 to 81 mg/day) are sufficient to irreversibly acetylate serine 530

of cyclooxygenase (COX)-1. This effect inhibits platelet generation of thromboxane A2,

resulting in an antithrombotic effect.

●Intermediate doses (650 mg to 4 g/day) inhibit COX-1 and COX-2, blocking

prostaglandin (PG) production, and have analgesic and antipyretic effects.

●High doses (between 4 and 8 g/day) are effective as antiinflammatory agents in

rheumatic disorders; the mechanism(s) of action at these high doses may include both

PG-dependent (particularly COX-2-dependent PGE2) and independent effects

uses 

• secondary prevention of atherosclerosis 

• in rheumatological conditions like kawasaki disease , APLA(APS)

• primary prevention of malignancies like colorectal carcinoma 

• in acute rheumatic fever 

side effects 

• gastritis 

• acute renal failure 

• reyes syndrome ( acute noninflammatory encephalopathy with fatty liver failure particularly in children with with varicella and influenza)